Discovering Endocrinology
Monday, May 21, 2012 by Belle:) in


       This called my attention! how does hormones secreted by glands affects bodily processes? Well, it helped me realized how wonderful body is. We must seek information about different hormones our body produces and their reaction to particular body parts and to the entire system. How will this hormones react if there is presence of alterations? The following information will help us enlighten our minds when it comes to endocrine system.



Figure 1:  Taken from http://www.macronutrients.net/homeostasis
Image shows the homeostasis 
Is an existence and maintenance of a quite constant environment within the body. Maintenance shows like a balance plane which everything should be stable to attain proper condition.


Homeostasis depends on the exact regulation of the organs and organ systems of the body. Among the rest of the system in our body, the nervous and  endocrine system that is being responsible in functioning regulation. As they work together they regulate and coordinate in the activity of most of all the body structure. When homeostasis is not maintained leading to discrepancy. Some of the discrepancies results to diseases such as Diabetes Mellitus and Addison’s disease.  During early time’s endocrine diseases has no effective treatment and diagnosis. People having condition often died. Now many treatments are available to treat endocrine diseases.  Numerous studies and diagnosis helps to promote life and could prevent death  




The regulatory functions of the nervous and endocrine system are similar in some aspect, but differ some important ways. The nervous system controls the activity of the tissues by transporting action potentials along the axon, which release chemical signals at their endings, near the cells they manipulate. The endocrine releases chemical signals in the circulatory system, which carries them throughout the body. Those cells that received chemical signal will produce responses.    


Source: http://encyclopedia.lubopitko-bg.com/The_Pituitary.html 








































 




 Overview of the pituitary gland, hormones secreted by the pituitary gland, and their target tissues.


Endocrine system is a communication network which release chemical that sends message throughout the circulation via blood stream. Its job is to excrete chemicals and hormone via blood and influence the performance or regulation of the tissue and organ of the work in specific ways. 




Endocrine System


Endocrine system serves multiple regulatory function some of them are including: water balance in which it system regulates by controlling the concentration of solute in the blood; uterine contraction and milk excretion in which system regulate the contraction of the uterus during child’s delivery and milk excretion in which helps to increase release of milk in the breast of lactating women; It modulates  Na, K, Ca ion content in the blood; it helps to control immune system by promoting the function and production of immune cells which helps to fight against harmful predators; and it also promote growth, metabolism and tissue maturation in which the system helps to regulate the development of tissues such as bones and muscles. It helps also in increase metabolism of body tissues and it also participate in development of physical and emotional properties.



Tabulation of Endocrine Glands, Hormones and their Target tissues
Glands
Hormones
Target Tissue
Response
Pituitary Gland (Anterior)
Tyroid stimulating hormone(TSH)
Thyroid gland  
Increases thyroid hormone secreted(thyroxine and triiodothyronine)

Adenocorticotropichormone(ACTH)
Adrenal cortex
Increases secretion of glucocoticoids hormones such as cortisol; increases skin pigmentation at high concentration.

Melanocyte-stimulating hormone(MSH)
Melanocytes in skin
Increases melanin production in melanocytes to make the skin darker in color

Luteinizing hormone
Ovary in female, testis in male
Promotes ovulation and progesterone production in the ovary ; testosterone synthesis and support for  sperm cell production in testis.

Follicle-stimulating hormone(FSH)
Follicles in ovary in females, seminiferous tubules in male
Promotes follicle  maturation and estrogen secretion in ovary; sperm cell production in testis.

Prolactin
Ovary and mammary gland in females, testis in males
Stimulates milk production and prolongs progesterone secretionfollowing ovulation and during pregnancy in women; increases sensitivity to LH in males.

Growth hormone
Most tissues
Increase protein synthesis, breakdown of lipids, and release of the fatty acids from cells: increase blood glucose level
Pituitary Gland (Posterior)
Oxytocin
Uterus
Mammary gland
Increases uterine contraction
Increases milk down from mammary glands

Antidiuretic hormone(ADH)
Kidney
Increases water re-absorption ( less H2O is lost as urine)
Thyroid glands
Thyroid hormones
Most cells of the body
Increases metabolic rates, essential for normal process of growth and maturation.

Calcitonin
Primarily bone
Decrease rate of bone breakdown; prevents large increase in blood Ca levels following a meal
Parathyroid glands
Parathyroid hormone
Bone, kidney
Increases bone breakdown by osteoclasts; increases vitamin D synthesis, essential for maintenance of the normal blood calcium levels  
Adrenal medulla
Epinephrine mostly, some nor epinephrine
Heart, blood vessels, liver, fat cells
Increases cardiac output; increases blood flow to skeletal muscles and heart; increases release of glucose and fatty acids into blood; in general, prepares the body for physical activity
Adrenal cortex
Mineralocorticoids
Kidneys; to lesser degree, intestine and sweat glands
Increases rate of sodium transport into body; increases potassium excretion; secondarily favour water retention

Glucocorticoids
Most tissues(e.g., liver, fats, skeletal muscles, immune tissues)
Increases fats and protein breakdown; increases glucose synthesis from amino acids; increases blood nutrient levels ; inhibits inflammation and immune response

Adrenal androgens
Most tissues
Insignificant in males; increases female sexual drive, pubic hair and axillary hair growth
pancreas
Insulin
Especially liver, skeletal muscle, adipose tissue
Increases uptake and use of glucose and amino acids

Glucagon
Primarily liver
Increases breakdown of glycogen and release of glucose into the circulatory system.
Reproductive organs



Testes
Testosterone
Most tissues
Aid in sperm production, maintenance of functional reproductive organs , secondary sexual characteristics , and sexual behavior.
Ovaries
Estrogen and progesterone
Most tissues
Aid in uterine and mammary gland development and function, external genitalia structure, secondary sexual characteristics, sexual behaviors, and menstrual cycle
Uterus, ovaries, inflamed tissues
Prostaglandins
Most tissues
Mediate inflammatory responses; increases uterine contractions, and ovulation
Thymus gland
Thymosin
Immune tissues
Promotes immune system development and structure
Pineal gland
Melatonin
At least the hypotalamus
Inhibits secretion of gonaotrophin-releasing hormones, thereby inhibiting reproduction




























































































































































REFERENCE:

Rod R. Seeley, Trent D. Stephens and Philip Tate, Essentials of Anatomy and Physiology 6th edition
Donald F. Calbreath, Clinical Chemistry: A Fundamental Text


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